Ann Ming is distraught when her 22-year-old daughter Julie goes missing. The police suggest that Julie must have fled to London to reunite with Julie's estranged husband, but Ann knows that Julie would never leave 5-year-old Kevin behind.

Lucy, a college student, along with her friends, spend their vacation at her family's home in Hawaii, which includes her pet chimpanzee, Ben. However, when Ben contracts rabies after being bitten by a rabid animal, the group must fight for their lives in order to avoid the now-violent chimp.