In the year 2075, mankind has reached a point where journeying between Earth, the moon and the space stations is part of daily life. However, the progression of technology in space has also resulted in the problem of the space debris, which can cause excessive and even catastrophic damage to spacecrafts and equipment.

Koyomi Araragi, a high school student, finds himself constantly encountering girls afflicted by supernatural "oddities." He dedicates himself to helping them, often with the aid of the eccentric specialist Meme Oshino. Each arc talks about a different girl's unique struggle and the mysterious cause of their affliction. The series explores themes of adolescence, personal growth, and the complexities of human relationships. It's known for its witty dialogue, stylistic animation, and unique narrative structure.