10 years after Dexter went missing in the eye of Hurricane Laura, we find him living under an assumed name in the small town of Iron Lake, New York. Dexter may be embracing his new life, but in the wake of unexpected events in this close-knit community, his Dark Passenger beckons.

Lucy, a college student, along with her friends, spend their vacation at her family's home in Hawaii, which includes her pet chimpanzee, Ben. However, when Ben contracts rabies after being bitten by a rabid animal, the group must fight for their lives in order to avoid the now-violent chimp.