Tekkaman Blade takes place in the year 2300 AD. On a certain moment, the Radam attack Earth. A few months after the beginning of the invasion, a Tekkaman appears, he calls himself Blade and with the help of the Space Knights, Blade starts to fight the Radam. But there are a few things that Blade isn't telling about his past.

Shinichi Chiaki is a first class musician whose dream is to play among the elites in Europe. Coming from a distinguished family, he is an infamous perfectionist; not only is he highly critical of himself, but of others as well. The only thing stopping Chiaki from leaving for Europe is his fear of flying. As a result, he's grounded in Japan.

During his 4th year at Japan's top music university, Chiaki happens to meet Noda Megumi—or as she refers to herself, Nodame. On the surface, she seems to be an unkempt girl with no direction in life. However, when Chiaki hears Nodame play the piano for the first time, he is in awe at the kind of music she plays. To Chiaki's dismay, Nodame moves into the apartment next to his and finds out that she is head-over-heels in love with him.

Kaya-chan attends Hanamugi Kindergarten, and she has an incredibly strong sixth sense. She secretly beats up the ghosts that stalk her friends and family, but in turn, she’s treated like a troublemaker since nobody understands her strange behavior. Everything changes when her teacher, Chie, discovers her secret. Kaya-chan's fists will go flying at any sinister spirits that show up!

Yugi Muto, a shy boy who loves all kinds of games, one day solves an ancient puzzle known as the Millennium Puzzle, causing his body to host the spirit of an ancient pharaoh.