Yu Takanashi, a former surgeon, joins the Comprehensive Diagnosis Department at Tenikai General Hospital, where he works alongside the brilliant yet eccentric Takao Ameku to solve mysterious medical cases.

Sakamichi Onoda is a high school student. He is an otaku, who loves animation and he is also a loner. Although he isn't good in sports, he decides to enroll in the bicycle racing club. Unexpectedly, he finds that he has a talent for bicycle racing. For the first time, he has a friend. Sakamichi Onoda exceeds his limits and finds pleasure in the sport of bicycle racing.

Two transfer students, Takashi Mitsuhashi and Shinji Itō, tired of their boring normal life and unpopularity, decide to take their arrival at a new school as an opportunity to reinvent their image, and become delinquents. The duo set out on various misadventures to become the greatest delinquents in all Japan!